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Photo of Loeb, Jeffrey

Jeffrey Loeb, MD, PhD

Director, ADRESai Project

Biomedical Informatics Core


Building & Room:

NPI Suite 657N


912 S. Wood St.

Office Phone:

(312) 996-1757


Dr. Loeb is a practicing neurologist, epileptologist and neuroscientist who currently holds the John S. Garvin Endowed Chair in Neurology and professor and head of neurology and rehabilitation , in addition to directing the CCTS Biomedical Informatics Core.

He received his A.B. in Chemistry, M.D. and Ph.D. from the University of Chicago.  After completed a residency in Neurology at the Massachusetts General Hospital in Boston, he joined the faculty of Harvard Medical School where he also had fellowship training in epilepsy at Harvard's Beth Israel Deaconess Hospital.  Dr. Loeb conducted postdoctoral work in the Department of Neurobiology at Harvard Medical School with Dr. Gerald Fischbach where he became interested in how understanding early neural development can teach us what goes wrong in human disease and suggest new treatments.

This and other work focusing on translating basic discoveries into new treatments has resulted in high profile publications, federal and foundation grants support, and a number of patents, including one for a targeted drug that blocks neuregulin signaling and shows promise in degenerative disease that blocks neural inflammation, such as ALS and Alzheimer’s.  His work in treating epilepsy patients led to a one-of-a-kind large-scale, systems biology project of human brain tissues that links the genes, molecular and cellular signals that underlie the abnormal electrical activities that characterize this common neurological disorder.   Dr. Loeb is director of the University of Illinois NeuroRepository and Chief Clinical Strategist for the Sturge-Weber Foundation.  To build on his scientific efforts and translate discoveries back to patients through public-private partnerships, he recently formed ‘I-BRAIN’ (Illinois Brain Analytics) in close collaboration and with support from the Discovery Partners Institute.