UICentre Drug Discovery Workshop 2019

Sponsoring Department: 
UICentre & Center for Clinical and Translational Science
Speaker: 
Jonathan A. Lee, PhD, Independent Drug Discovery Investigator, PDD4Patients LLC & David C. Swinney, PhD, Chief Executive Officer, Institute for Rare and Neglected Diseases Drug Discovery
Event Time: 
8:00am - 1:00pm
Event Location: 
UIC College of Pharmacy, 833 S. Wood Street, Room 134-3
Contact Email: 
lbloem@uic.edu

Abstract:

“Preclinical strategies that are used to identify potential drug candidates include target-based screening, phenotypic screening, modification of natural substances and biologic-based approaches. To investigate whether some strategies have been more successful than others in the discovery of new drugs, we analysed the discovery strategies and the molecular mechanism of action (MMOA) for new molecular entities and new biologics that were approved by the US FDA between 1999 and 2008. The results show that the contribution of phenotypic screening to the discovery of first-in-class small-molecule drugs exceeded that of target-based approaches - with 28 and 17 of these drugs coming from the two approaches, respectively - in an era in which the major focus was on target-based approaches.”

Swinney, D. C., and Anthony, J. (2011) How were new medicines discovered?, Nat Rev Drug Discov 10, 507-519.

Workshop Topics

  • Impact of Phenotypic Drug Discovery (PDD) on novel medicines
  • PDD case studies
  • How PDD differs from target based approaches
  • Guidelines for implementing PDD
  • Approaches to target/pathway deconvolution following PDD

Full speaker list and agenda forthcoming!