UICentre Drug Discovery Workshop 2019
“Preclinical strategies that are used to identify potential drug candidates include target-based screening, phenotypic screening, modification of natural substances and biologic-based approaches. To investigate whether some strategies have been more successful than others in the discovery of new drugs, we analysed the discovery strategies and the molecular mechanism of action (MMOA) for new molecular entities and new biologics that were approved by the US FDA between 1999 and 2008. The results show that the contribution of phenotypic screening to the discovery of first-in-class small-molecule drugs exceeded that of target-based approaches - with 28 and 17 of these drugs coming from the two approaches, respectively - in an era in which the major focus was on target-based approaches.”
Swinney, D. C., and Anthony, J. (2011) How were new medicines discovered?, Nat Rev Drug Discov 10, 507-519.
- Impact of Phenotypic Drug Discovery (PDD) on novel medicines
- PDD case studies
- How PDD differs from target based approaches
- Guidelines for implementing PDD
- Approaches to target/pathway deconvolution following PDD
Full speaker list and agenda forthcoming!