Biomedical Informatics Core Personnel
Jeffrey A Loeb, MD, PhD, Core Director
Dr. Jeffrey Loeb is a clinician-scientist with a focus on neurological disorders, informatics, and translational research. He holds the John S. Garvin Chair and is Professor and Head of the department of Neurology and Rehabilitation. Dr. Loeb’s clinical specialty is on the evaluation and treatment of patients with epilepsy. He is an expert in quantitative measurements of epileptic electrical activity in the brain using EEG, or electroencephalography and the medical and surgical management of patients with hard to control seizures. Loeb has linked his clinical and research interests through pioneering a unique systems biology approach that analyzes gene, protein, and metabolite expression in human brain and linking these to the electronic health record, brain imaging, brain electrical recordings, and histopathology to identify new ways to diagnose and treat disease. In addition to his role at CCTS, he is the founding director of the University of Illinois NeuroRepository: A combined data and tissue repository with an underlying goal of finding new biomarkers and targets for brain disorders. Dr. Loeb trained in chemistry and biochemistry for his undergraduate and PhD degrees at the University of Chicago followed by residency training in neurology at the Massachusetts General Hospital in Boston. He subsequently combined epilepsy training at Beth Israel Deaconess Hospital with research in the Department of Neurobiology at Harvard working with Gerald Fischbach on neuregulin in nervous system development. He came to the University of Illinois in 2013 after advancing his research and clinical careers at Wayne State University in Detroit Michigan and was Associate Director of the Center for Molecular Medicine and Genetics. He is also leader in the field of growth factor signaling in motor neurons and has developed an innovative drug-targeting technology He holds multiple patents.
Edward Barbour, MS, Director
Mr. Barbour has more than ten years of experience in bioinformatics. He received his BS in Computer Science from Oakland University, Rochester, MI; MS in Bioinformatics at University of Michigan, Ann Arbor, and is currently a PhD candidate in Computational Medicine and Bioinformatics at the University of Michigan. Previously, he was Director of the Informatics Core at The Rockefeller University Hospital in New York City. Most recently he served as a pharmacogenomics systems architect in a unique public/private partnership between the University of Michigan and AssureX Health. Mr. Barbour was the first Vice President of Scientific Content for Compendia Bioscience of Ann Arbor, MI. Additionally, Mr. Barbour has fifteen years of successful commercial software development, designing and developing software used by Fortune 500 companies, worldwide. He is also expert in data modeling and data base design and has lead successful implementations of integrated research systems for The Rockefeller University Hospital including successful machine learning projects.
Jacqueline Clark, MS, RHIA, Manager of Clinical Research Informatics Operations & Projects
Jacqueline currently serves as part of the CCTS Biomedical Informatics Core and Clinical Research Data Warehouse team. She received her BS in Health Information Management (HIM) and MS in Management Information Systems with a focus on Healthcare IT at the University of Illinois and is credentialed as a Registered Health Information Administrator. During her time in the HIM program, Jacqueline worked in the medical record departments at both UI Health and the Rehabilitation Institute of Chicago. She later served as a clinical research coordinator and business manager in the UIC Department of Medicine (DOM) for nearly 4 years. While with DOM, Jacqueline had a strong interest in medical coding and billing data, building and optimizing information systems, as well as clinical quality improvement research and led a variety of projects related to those domains. She was later the business manager and project manager at the UIC Center for Research Informatics within the Resource Resources Center and delved further into the field of clinical informatics. Her expertise includes medical coding and classification systems, health information systems, management and use of medical record data, process and quality improvement, and project management.
Xiao Dong, PhD, Research Specialist
Xiao Dong received his PhD in Informatics from Indiana University Bloomington in 2010. Prior to joining the Biomedical Informatics Core, he was Senior Research Associate at the Center for Clinical Investigation at Case Western Reserve University. Dr. Dong is currently the informatics lead for UIC’s CAPriCORN/PCORNet project and a data analyst on the Clinical Research Data Warehouse (CRDW) team. A technical reviewer for the American Medical Informatics Association (AMAI) since 2011, Dr. Dong leads innovation efforts within the CRDW team. His paper “Leveraging Big Data Technology within i2b2 Platform,” published in the AMIA Clinical Research Informatics (CRI) 2014 summit proceedings, led to an invited talk at Harvard Medical School (at the invitation of Dr. Shawn Murphy). As a domain expert in applying cutting edge big data and deep learning technologies to clinical informatics, Dr. Dong's research is focused primarily on data modeling and privacy protection. His latest project, a “Deep Learning Enabled i2b2 Emulator,” is currently under review for the AMIA CRI 2018 joint summit.
Subhash Kumar Kolar Rajanna, MD, MS, BI Research Specialist
Subhash Kumar serves as part of the Clinical Research Data Warehouse team. With his clinical and biomedical research background, he brings unique skills and expertise to support the needs of the clinical and translational researchers. He has extensive experience in the design and implementation of Clinical Information Systems and developing analytical solutions to improve patient health. His research interests focus on the secondary use of EHR data for improved clinical and epidemiological research, with the emphasis on data mining and natural language processing.
David Randolph, MEng, Research Specialist
David A. Randolph, formerly Principal Staff Software Engineer at Motorola Mobility (a Lenovo company), joined CCTS in September 2017 and focuses primarily on the care and feeding of the Clinical Research Data Warehouse. Prior to joining Motorola in 1999, Mr. Randolph was Staff Software Engineer at IBM Printing Systems, Associate Editor at the University of Wisconsin-Madison, and a teacher in Illinois public schools. He earned a BS in secondary education (teaching of English) from the University of Illinois at Urbana-Champaign in 1989, a BS in computer sciences from the University of Wisconsin-Madison in 1996, a graduate certificate in bioinformatics from UIC in 2006, and an ME in computer science from the University of Colorado Boulder in 2009. Currently a PhD candidate in the Department of Computer Science at UIC, Mr. Randolph's research interests include natural language processing (NLP), biomedical informatics, educational technology, and music computing. At UIC, he is advised by Prof. Barbara Di Eugenio and is affiliated with the NLP Laboratory.
Eugene M. Sadhu, MD, Research Specialist
Dr. Sadhu serves as part of the Clinical Research Data Warehouse team. His background as a graduate of the UIC College of Medicine and fellowship in Biomedical Informatics at the University of Chicago Department of Surgery and Computation Institute provide the warehouse team with clinical insight into the problem domain. His prior research experience in high-performance computing and professional work software engineering further provide skills in bridging technical knowledge and clinical expertise.
Andrew Boyd, MD, Lead Clinical Liaison for Informatics
Andrew Boyd provides expertise in clinical data resources and will facilitate consultative services and collaborations between informatics experts and clinical and translational researchers. Dr. Boyd is a Research Assistant Professor in both the College of Medicine in the Department of Medical Education and the College of Applied Health Sciences in the Department of Biomedical and Health Information Sciences. He assisted with the development of the University of Michigan's NIH-supported Honest Broker System, a federated clinical research system that integrated diverse clinical and research resources for centralized accessibility.